Enfocus (Booth 246) is demonstrating PitStop Pro 11 and PitStop Server 11, which marks the introduction of 'Smart Preflight & Correction', delivering complete PDF quality control and the ability to fix problems in seconds. It provides users with a flexible solution to preflight and correct PDF files according to their specific production requirements.
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The new version introduces the concept of 'Variable Sets', a group of variables to be used when preflighting or correcting PDF file. A variable within PitStop Server 11 points to specific information in an XML or JDF job ticket. When the job ticket arrives along with the PDF file, the right values are automatically provided for the preflight check. All customer-specific requirements are checked and corrected without the need for manual intervention. Variables are also supported by Actions Lists allowing job specific corrections. Through the ability to use tickets coming from MIS, web portal or order entry systems, PitStop Server 11 offers significant opportunities to automate high-volume production processes. It allows users to gain competitive edge and win more business. PitStop Server also seamlessly fits into Enfocus Switch to provide preflighting and auto-correction in a fully automated way.
UPDATE 2021-10-08: Enfocus Pitstop has released an update that now resolves the error that was brought about by the update of Adobe Acrobat DC. However, I will leave the article posted for posterity.
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Reeves was born to an American father and a Filipino mother. He grew up on the Hawaiian island of Maui. Reeves struggled academically, and directed his energy instead towards teaching himself to code. He briefly attended Northern Arizona University upon graduating high school but dropped out to focus on work, securing a job as a software contractor for the U.S. government.[citation needed]
Kraksnax (aka KSX) is a contemporary Commodore 64 NTSC-focused software, graphics preservation, cracking, restoration group and website. Releases are particularly created on and produced for NTSC experience, although most often compatible with PAL machines. Releases always provide disk format but also .tap and .prg format, when applicable, and usually feature newly created intro graphics as well as program-format documentation or even game modifications. Kraksnax also produces new software and even games based on, or expanded from vintage sources (redux), and various restoration. Additionally the group release traditional 'cracks' or software repackaged with the intention towards incorporating various alternative, beneficial elements or for purposes of preservation in the contemporary age.
(7-2021) Most software, especially 'cracks' of pre-existing vintage software, are almost always executed and tested on generally: one of 5 C64 Breadbin models, both US and Canadian NTSC; 1541/1571 model disk drives; C2N 1530 or Data Master datasette models and through a plethora of vintage techniques, hardware and software. Currently, the group is open to collaboration, processing, testing and packaging of any creator's new work and be reached through their website.
This study explores the role of G-protein-coupled receptor-intracellular signaling in the development of P450-mediated insecticide resistance in mosquitoes, Culex quinquefasciatus , focusing on the essential function of the GPCRs and their downstream effectors of Gs alpha subunit protein (Gαs) and adenylyl cyclase (ACs) in P450-mediated insecticide resistance of Culex mosquitoes. Our RNAi-mediated functional study showed that knockdown of Gαs caused the decreased expression of the downstream effectors of ACs and PKAs in the GPCR signaling pathway and resistance P450 genes, whereas knockdown of ACs decreased the expression of PKAs and resistance P450 genes. Knockdown of either Gαs or ACs resulted in an increased susceptibility of mosquitoes to permethrin. These results add significantly to our understanding of the molecular basis of resistance P450 gene regulation through GPCR/Gαs/AC/cAMP-PKA signaling pathways in the insecticide resistance of mosquitoes. The temporal and spatial dynamic analyses of GPCRs, Gαs, ACs, PKAs, and P450s in two insecticide resistant mosquito strains revealed that all the GPCR signaling pathway components tested, namely GPCRs, Gαs, ACs and PKAs, were most highly expressed in the brain for both resistant strains, suggesting the role played by these genes in signaling transduction and regulation. The resistance P450 genes were mainly expressed in the brain, midgut and malpighian tubules (MTs), suggesting their critical function in the central nervous system and importance for detoxification. The temporal dynamics analysis for the gene expression showed a diverse expression profile during mosquito development, indicating their initially functional importance in response to exposure to insecticides during their life stages.
As more power electronic-based devices enable the development of high-bandwidth AC microgrids, the topic of microgrid power distribution stability has become of increased interest. Recently, researchers have proposed a relatively straightforward method to assess the stability of AC systems based upon the time-constants of sources, the net bus capacitance, and the rate limits of sources. In this research, a focus has been to develop a hardware test system to evaluate AC system stability. As a first step, a time domain model of a two converter microgrid was established in which a three phase inverter acts as a power source and an active rectifier serves as an adjustable constant power AC load. The constant power load can be utilized to create rapid power flow transients to the generating system. As a second step, the inverter and active rectifier were designed using a Smart Power Module IGBT for switching and an embedded microcontroller as a processor for algorithm implementation. The inverter and active rectifier were designed to operate simultaneously using a synchronization signal to ensure each respective local controller operates in a common reference frame. Finally, the physical system was created and initial testing performed to validate the hardware functionality as a variable amplitude and variable frequency AC system.
This work reviews recent developments in the use of magnetic susceptibility contrast for human MRI, with a focus on the study of brain anatomy. The increase in susceptibility contrast with modern high field scanners has led to novel applications and insights into the sources and mechanism contributing to this contrast in brain tissues. Dedicated experiments have demonstrated that in most of healthy brain, iron and myelin dominate tissue susceptibility variations, although their relative contribution varies substantially. Local variations in these compounds can affect both amplitude and frequency of the MRI signal. In white matter, the myelin sheath introduces an anisotropic susceptibility that has distinct effects on the water compartments inside the axons, between the myelin sheath, and the axonal space, and renders their signals dependent on the angle between the axon and the magnetic field. This offers opportunities to derive tissue properties specific to these cellular compartments.
Evolution of pest resistance reduces the efficacy of insecticidal proteins from the gram-positive bacterium Bacillus thuringiensis (Bt) used widely in sprays and transgenic crops. Recent efforts to delay pest adaptation to Bt crops focus primarily on combinations of two or more Bt toxins that kill the same pest, but this approach is often compromised because resistance to one Bt toxin causes cross-resistance to others. Thus, integration of Bt toxins with alternative controls that do not exhibit such cross-resistance is urgently needed. The ideal scenario of negative cross-resistance, where selection for resistance to a Bt toxin increases susceptibility to alternative controls, has been elusive. Here we discovered that selection of the global crop pest, Helicoverpa armigera, for >1000-fold resistance to Bt toxin Cry1Ac increased susceptibility to abamectin and spineotram, insecticides derived from the soil bacteria Streptomyces avermitilis and Saccharopolyspora spinosa, respectively. Resistance to Cry1Ac did not affect susceptibility to the cyclodiene, organophospate, or pyrethroid insecticides tested. Whereas previous work demonstrated that the resistance to Cry1Ac in the strain analyzed here is conferred by a mutation disrupting an ATP-binding cassette protein named ABCC2, the new results show that increased susceptibility to abamectin is genetically linked with the same mutation. Moreover, RNAi silencing of HaABCC2 not only decreased susceptibility to Cry1Ac, it also increased susceptibility to abamectin. The mutation disrupting ABCC2 reduced removal of abamectin in live larvae and in transfected Hi5 cells. The results imply that negative cross-resistance occurs because the wild type ABCC2 protein plays a key role in conferring susceptibility to Cry1Ac and in decreasing susceptibility to abamectin. The negative cross-resistance between a Bt toxin and other bacterial insecticides reported here may facilitate more sustainable pest control. PMID:26872031 2ff7e9595c
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